Comparison Between MRI Alone or Combined With Positron Emission Tomography for Brain Metastasis Diagnosis

Official Title

Differentiation Between Radionecrosis and Tumour Recurrence for Post-stereotactic Radiosurgery Follow-up by Pharmacokinetic Analyses in Perfusion MRI and Positron Emission Tomography


During gamma scalpel treatment of brain tumours and metastases, a follow-up magnetic resonance imaging (MRI) scan is performed. The radiologist who reviews the MRI assesses whether there is an increase in signal at the tumour site. This increase potentially indicates that the treatment was not effective. However, in 25% of cases (one in four people), this signal enhancement is not due to ineffective treatment, but to inflammation (swelling/damage) and tissue death around the tumour. This is why when an increase in signal is detected, additional follow-up is essential. The standard additional follow-up has an accuracy of about 83%. This is an observational study on patients with brain metastatis comparing MRI alone or combined to PET-FET to improve accuracy of diagnosis of metastasis recurrence.

Trial Description

Primary Outcome:

  • Comparison of novel MRI method with current MRI exam method
  • Comparison of DCE-MRI method with FET PET

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Canadian Cancer Society

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