A Study of SEA-CD40 Given With Other Drugs in Cancers

Official Title

An Open-label, Phase 2 Basket Study of SEA-CD40 Combination Therapies in Advanced Malignancies


This trial is being done to see if an experimental drug (SEA-CD40) works when it's given with other cancer drugs to treat some types of cancer. It will also study side effects from the drug.

There are 2 parts in this trial. In one part, participants have melanoma that has come back after treatment or can't be removed by surgery. Participants in this part will get SEA-CD40 and pembrolizumab. In the other part, participants have non-small cell lung cancer (NSCLC) that has spread through their body. These participants will get SEA-CD40, pembrolizumab, carboplatin, and pemetrexed.

Trial Description

Primary Outcome:

  • Confirmed Objective Response Rate (ORR)
Secondary Outcome:
  • Incidence of adverse events (AEs)
  • Incidence of laboratory abnormalities
  • Incidence of dose alterations
  • Disease control rate (DCR) per investigator assessment
  • Duration of response (DOR) per investigator assessment
  • Progression-free survival (PFS) per investigator assessment
  • Overall survival (OS)

View this trial on ClinicalTrials.gov

Interested in this trial?

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Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society