Chest Lymph Node Sampling in Patients With Advanced Lung Cancer to be Treated With Curative-intent Radiation Treatment

Official Title

Endoscopic Nodal Staging in Oligometastatic Non-small Cell Lung Cancer (NSCLC) Being Treated With Stereotactic Ablative Radiation Therapy (ENDO-SABR)


This study will investigate the role of sampling suspicious chest lymph nodes with a procedure called endobronchial ultrasound-guided transbronchial fine needle aspiration (EBUS-TFNA) or transesophageal ultrasound-guided fine needle aspiration (EUS-FNA) in patients planned to receive radical dose radiation.

This study will use Stereotactic Ablative Radiation Therapy (SABR) for treatment methods. SABR is a newer radiation treatment that delivers high-dose, precise radiation to small tumours and can be delivered more accurately than with older radiation treatment methods. It is considered a standard treatment for small lung cancers, and select cancers that have spread to the brain.

The purpose of this study is to compare if the lymph node sampling procedure is valuable for determining the extend of nodal disease in metastatic Non-Small Cell Lung Cancer (NSCLC) compared to imaging alone.

Trial Description

Primary Outcome:

  • Changes to treatment intent and/or plan
Secondary Outcome:
  • Determine the proportion of patients with occult mediastinal metastasis
  • Determine the sensitivity and specificity of radiologic staging of hilar/mediastinal lymph nodes
  • Identify the total number of lymph nodes sampled per procedure
  • Identify the nodal stations sampled
  • Determine the proportion of patients with complications of endoscopic procedure

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Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society