Dual Tracer (68Ga-DOTATATE and 18F-FDG) PET Imaging in G2 & G3 Gastroenteropancreatic Neuroendocrine Tumours

Official Title

Combined 68Ga-DOTATATE and 18F-FDG PET/CT Imaging in Patients With Well-differentiated, G2-G3, Gastroenteropancreatic (GEP)-Neuroendocrine Tumours (NETs) - A Pilot Study

Summary:

The variable clinical outcome of patients with G2 & G3 well diff GEP-NETs makes the selection of an optimal treatment strategy challenging. Initial data suggests that high DOTATATE uptake and low FDG uptake are suggestive of low grade disease, with an indolent course. Conversely, low DT uptake and high FDG uptake are suggestive of high-grade/ aggressive disease. G2/3 GEP NETs may be biologically diverse; clinically relevant cohort for dual-tracer PET imaging. Our secondary objectives are 1. To determine the distribution of PETNET scores derived from 18F-FDG & 68Ga-DT PET in patients with G2 & G3 well diff GEP-NETs. 2. To determine the proportion of patients in whom the addition of 18F-FDG PET data results in a change in planned clinical management. To assess intra-individual variability in SSTR expression & glucose metabolism (as seen on DT and FDG PET) across different tumour sites within the same patient. 2) To determine whether a correlation exists between tumour texture features on 68Ga-DT & FDG PET to tumour grade and Ki 67 index. 3) To assess for an association between tumour texture features on 68Ga-DT PET and glucose metabolism; and/or an association between tumour texture features on FDG PET and SSTR expression.

Trial Description

Primary Outcome:

  • Discordance in tracer uptake:
  • Impact to patient management:
Secondary Outcome:
  • Intraindividual tumour heterogeneity:
  • Tumour texture geatures as predictors of tumour grade:
  • Tumour texture features as predictors of tumour metabolism and somatostatin receptor expression:
The variable clinical outcome of patients with G2 and G3 well differentiated GEP-NETs makes the selection of an optimal treatment strategy challenging. A subject with 68Ga-DOTATATE uptake on all lesions without FDG uptake is likely to have low-grade, metabolically inactive disease, leading to an indolent disease course and may also be a predictive biomarker in subjects being considered for PRRT. Conversely, avidity on 18F-FDG PET/CT and non-avidity on 68Ga-DOTATATE may indicate a high-grade NET, and would predict resistance to PRRT, suggesting that a more "aggressive" approach with systemic chemotherapy might be beneficial. Therefore, the prospective assessment of PETNET score in patients with G2 or G3 GEP NETs, which may be biologically diverse is the most clinically relevant group for dual-tracer PET imaging. Primary Objectives: 1. To determine the distribution of PETNET scores derived from 18F-FDG and 68Ga-DOTATATE PET/CT in patients with G2 and G3 well differentiated GEP-NETs. 2. To determine the proportion of patients in whom the addition of 18F-FDG PET/CT data results in a change in planned clinical management. Secondary Objectives: 1. mTo determine whether there is intra-individual variability in somatostatin receptor expression and glucose metabolism (as seen on DOTATATE PET and FDG PET, respectively) across different tumour sites within the same patient. 2. To determine whether a correlation exists between tumour texture features on 68Ga-DOTATATE PET and FDG PET to tumour grade and Ki67 index. 3. To assess if an association exists between tumour texture features on 68Ga-DOTATATE PET and glucose metabolism; and/or an association between tumour texture features on FDG PET and somatostatin receptor expression.

View this trial on ClinicalTrials.gov

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Resources

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