A Study of VS-6766 v. VS-6766 + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer With and Without a KRAS Mutation

Official Title

A Phase 2 Study of VS-6766 (Dual RAF/MEK Inhibitor) Alone and In Combination With Defactinib (FAK Inhibitor) in Recurrent Low-Grade Serous Ovarian Cancer (LGSOC)

Summary:

This study will assess the safety and efficacy of VS-6766 monotherapy and in combination with Defactinib in subjects with recurrent Low-Grade Serous Ovarian Cancer (LGSOC)

Trial Description

Primary Outcome:

  • Part A: Determine optimal regimen of VS-6766 monotherapy or in combination with defactinib
  • Part B: To determine the efficacy of the optimal regimen identified from Part A
Secondary Outcome:
  • Overall Response Rate as assessed by Investigator
  • Duration of Response (DOR)
  • Disease Control Rate (DCR)
  • Progression Free Survival (PFS)
  • Overall Survival (OS)
This is a multicentre, randomized, open-label Phase 2 study designed to evaluate safety and tolerability and preliminary efficacy of VS-6766 versus VS-6766 in combination with defactinib in subjects with molecularly profiled recurrent LGSOC.

View this trial on ClinicalTrials.gov

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Resources

Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society