Study of Ibrutinib and Rituximab in Treatment Naïve Follicular Lymphoma

Official Title

A Multicentre, Randomized, Double-blind, Placebo-controlled Phase 3 Study of the Bruton's Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Combination With Rituximab Versus Placebo in Combination With Rituximab in Treatment Naïve Subjects With Follicular Lymphoma (PERSPECTIVE)


The purpose of this study is to evaluate whether the addition of ibrutinib will result in prolongation of progression-free survival (PFS) when compared with rituximab alone in treatment naïve subjects with follicular lymphoma.

Trial Description

Primary Outcome:

  • Progression-free survival
Secondary Outcome:
  • Overall Response Rate (ORR)
  • Overall Survival
  • Infusion-Related Reaction Rate
  • Adverse Events

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Canadian Cancer Society

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