Hybrid-APC Margin Ablation to Prevent Post EMR Adenoma Recurrence

Official Title

Hybrid-APC Margin Ablation to Prevent Post EMR Adenoma Recurrence


Endoscopic Mucosal Resection (EMR) is the current standard for effective endoscopic resection of such colon adenomas. If resection is possible in one piece (so called "en bloc" resection) then recurrence rates are low. However, most non-pedunculated polyps >2 cm are removed in pieces ("piece-meal" resection) which leads to disease recurrence rates between 12-30%. In the March 2019 issue of Gastroenterology Bourke et al. presented that post EMR ablation of the resection margins using soft coagulation with the tip of a resection snare reduces adenoma recurrence to 5% compared to 21% recurrence found in the control group. Hybrid Argon Plasma Coagulation (h-APC) combines an ablation technique (APC) with the option for submucosal saline injection using a high-pressure water jet. The technique allows to lift dysplastic epithelium thus creating a safety cushion under the mucosa is lifted with a saline injection and then to ablate larger areas more thoroughly and with a higher energy setting, with a low risk for side effects or complications.

Trial Description

Primary Outcome:

  • Evaluate adenoma recurrence rate
  • Evaluate complete adenoma eradication rates

View this trial on ClinicalTrials.gov

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Canadian Cancer Society

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