Study of MK-4830 as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumours (MK-4830-001)

Official Title

A Phase 1 Open Label, Multi-Arm, Multicentre Study of MK-4830 as Monotherapy and in Combination With Pembrolizumab for Participants With Advanced Solid Tumours

Summary:

This study will determine the safety and tolerability and to establish a preliminary recommended Phase 2 dose of MK-4830 administered as monotherapy and in combination with pembrolizumab (MK-3475) in adults with advance solid tumours.

Trial Description

Primary Outcome:

  • Dose-Limiting Toxicities (DLTs)
  • Adverse Events (AEs)
  • Study Treatment Discontinuations Due to AEs
Secondary Outcome:
  • Area Under the Curve (AUC) of Plasma MK-4830
  • Minimum Drug Concentration (Cmin) of Plasma MK-4830
  • Maximum Drug Concentration (Cmax) of Plasma MK-4830

View this trial on ClinicalTrials.gov

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Resources

Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society