Cognitive Support Program for Patients With Brain Metastases

Official Title

Cognitive Support Program for Patients With Brain Metastases

Summary:

This study evaluates the feasibility and preliminary efficacy of a brief cognitive-behavioural program designed to improve cognitive functioning in people with brain metastases.

Trial Description

Primary Outcome:

  • Functional Assessment of Cancer Therapy - Cognitive
Secondary Outcome:
  • Frontal Systems Behaviour Scale
  • Hopkins Verbal Learning Test - Revised
  • Trail Making Test
  • Wechsler Digit Span Test
  • BADS Zoo Map Test
  • Controlled Oral Word Association Test
  • Functional Assessment of Cancer Therapy - Brain
  • Positive and Negative Affect Schedule
  • Hospital Anxiety and Depression Scale
  • Illness Intrusiveness Rating Scale

Cognitive impairments (such as problems with attention, executive functions, memory and language abilities) are common in people with brain metastases as a result of disease and/or treatment effects. These impairments can significantly limit functional independence, participation in valued roles and activities, and overall quality of life.

Building on research in other cognitively-impaired populations, we designed a brief, structured, patient-centred Cognitive Support Program (CSP) for brain metastases patients, who have the option of participating with a caregiver. Program contents include supportive psychoeducation, mindfulness practice, and strategy training (e.g., strategies to improve memory or concentration). This prospective, single-arm study will enroll 24 brain metastases patients to evaluate the feasibility and preliminary efficacy of the CSP. A battery of outcome measures is administered (1) prior to intervention, (2) after completing the CSP, and (3) after an additional 3 months to evaluate longer-term outcomes. Feasibility assessment will include program retention and adherence. Reliable change analyses will examine treatment effects, with regression analyses to explore moderating effects of select patient, disease and treatment factors (e.g., severity of baseline cognitive impairment, number of brain lesions, cranial radiation dose and distribution). Results of this trial will inform further development and implementation of evidence-based supportive care for cognitively-impaired brain metastases patients.

View this trial on ClinicalTrials.gov

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Resources

Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society