Polycystic Ovary Syndrome and Exercise

Official Title

The Impact of Continuous Aerobic Exercise and High-Intensity Interval Training on Reproductive Outcomes in Polycystic Ovary Syndrome: A Pilot Randomized Controlled Trial.

Summary:

Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder characterized by oligo-ovulatory menstrual dysfunction, androgen excess and polycystic ovaries. It affects ten to fifteen percent of reproductive-age women and has been associated with complications in reproductive, metabolic and cardiovascular health. Current Clinical Practice Guidelines suggest exercise and weight loss for PCOS, although their specific roles in improving PCOS-related symptoms are uncertain. Non-pharmacological treatments are appealing to many reproductive age women. There is preliminary evidence that exercise in PCOS may increase menstrual regularity, ovulation, cardiorespiratory fitness, health-related quality of life (HRQOL) and self-esteem, and decrease body fat and insulin resistance. These studies have been limited by short durations and lack of randomization or appropriate control groups. High-intensity interval training (HIIT), which involves brief intervals of near-maximal exercise alternating with lower-intensity exercise, is becoming increasingly popular in the exercise community. In some non-PCOS trials, HIIT resulted in improved cardiovascular fitness and greater fat loss compared with continuous aerobic exercise. No other trials are currently on-going that are comparing HIIT with continuous aerobic exercise training in women with PCOS (as confirmed by searches of the literature and the clinical trials registry maintained by the US NIH).

Trial Description

Primary Outcome:

  • Ovulation Rate
Secondary Outcome:
  • Hirsutism
  • Menstrual Cycle Length
  • Luteal Phase Length
  • Pregnancy
  • Spontaneous Abortions
  • Live Births
  • Body Weight
  • Body Mass Index
  • Waist Circumference
  • Blood Pressure
  • Hemoglobin A1c
  • Fasting Glucose
  • Fasting Insulin
  • Homeostatic Model of Insulin Resistance (HOMA-IR)
  • HOMA-2
  • Lipids - total cholesterol, LDL, HDL, triglycerides
  • Liver Enzymes - ALT, GGT
  • Cardiorespiratory Fitness
  • Health-Related Quality of Life
  • Obstructive Sleep Apnea
  • Participant Satisfaction
  • Participant Recruitment - Number of Participants Screened
  • Participant Recruitment - Recruitment Method
  • Participant Recruitment - Number of Participants That Met Criteria
  • Participant Recruitment - Number of Participants That Signed Informed Consent
  • Participant Dropout
  • Adherence to Menstrual Cycle Tracking
  • Adherence to Ovulation Prediction Kit (OPK) Testing
  • Adherence to Exercise Sessions
  • Change in Gut Microbiota Composition
  • Daily Physical Activity Level
  • Physical Activity Enjoyment

View this trial on ClinicalTrials.gov

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Resources

Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society