An Investigational Immunotherapy Study of Nivolumab in Combination With Rucaparib, Docetaxel, or Enzalutamide in Metastatic Castration-resistant Prostate Cancer

Official Title

A Phase 2 Study of Nivolumab in Combination With Either Rucaparib, Docetaxel, or Enzalutamide in Men With Castration-resistant Metastatic Prostate Cancer


The purpose of this study is to assess the safety and efficacy of nivolumab in combination with rucaparib, docetaxel, or enzalutamide in participants with castration-resistant prostate cancer that has spread.

Trial Description

Primary Outcome:

  • Objective Response Rate (ORR)
  • Prostate-specific antigen response rate (RR-PSA)
Secondary Outcome:
  • Radiographic progression-free survival (rPFS)
  • Time to response (TTR)
  • Duration of response (DOR)
  • Time to prostate-specific antigen progression (TTP-PSA)
  • Overall Survival (OS)
  • Incidence of adverse events (AEs)
  • Incidence of serious adverse events (SAEs)

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Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society