Calypso Guided High Precision Stereotactic Ablative Radiosurgery for Lung Tumours Using Real-Time Tumour Tracking & Respiratory Gating: A Seamless Phase I/II Prospective Clinical Trial
This is a single arm seamless phase I/II prospective cohort study. Patients with early stage Non-Small Cell Lung Cancer (T1-T2N0M0) or those with a single pulmonary metastasis of a known malignancy (either following radical treatment or systemic therapy) will be offered participation in this study. Participants will have three tumour locator beacons placed with a flexible bronchoscope in the small bronchial airways in proximity (<3cm) from their lung tumours. These tumour locator beacons will provide real-time positional data and will allow for smaller treatment volumes of Stereotactic Ablative Radiosurgery (SABR) and also allow for a specialized form of treatment delivery known as respiratory gated SABR. This is expected to result in higher precision radiotheapy delivery with less radiation therapy dose to healthy tissues which are in close proximity to the lung tumours.
Primary Outcome:
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