Feasibility Trial in Men With Hormone Sensitive Oligometastatic Prostate Cancer

Official Title

Randomized Feasibility Trial of Prostate Radiation Therapy vs Prostatectomy in Men With Hormone Sensitive Oligometastatic Prostate Cancer


Patients with hormone sensitive oligometastatic prostate cancer (≤ 5 metastatic tumours outside of regional pelvic nodes with no more than 3 in any organ system) and no previous treatment to prostate will be treated with intermittent androgen deprivation therapy +/- chemotherapy, stereotactic radiation therapy to all metastases, and either radical prostatectomy or radiation therapy.

Trial Description

Primary Outcome:

  • Patients willing to accept their randomization
Secondary Outcome:
  • Toxicity
  • Efficacy
Investigators propose to do a randomized feasibility trial comparing RP vs RT to the prostate in the setting of hormone sensitive oligometastatic prostate cancer. SBRT will be used to treat all of the metastases, and this will be combined with an intermittent ADT approach. Adding systemic chemotherapy will be allowed. Given the past difficulties of randomizing patients between RP and RT in localized prostate cancer studies (like SPIRIT), investigators feel a small feasibility project is the first step. In the setting of metastatic disease, where radical treatment is not routine standard of care, we hope that patients will be more inclined to accept randomization. If patients do not accept their assigned randomization (ie they prefer RP even though they are randomized to RT, or vice versa), they will still be treated with their prostate intervention of choice and followed for their outcomes.

View this trial on ClinicalTrials.gov

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Canadian Cancer Society

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