Dose-Escalation Study of BFCR4350A in Participants With Relapsed or Refractory Multiple Myeloma (R/R MM)

Official Title

An Open-Label, Multicentre, Phase I Trial Evaluating the Safety and Pharmacokinetics of Escalating Doses of BFCR4350A in Patients With Relapsed or Refractory Multiple Myeloma

Summary:

This is a phase I, multicentre, open-label, dose-escalation study of BFCR4350A administered as a single agent by IV infusion to participants with relapsed or refractory multiple myeloma (R/R MM).

Trial Description

Primary Outcome:

  • Incidence and Severity of Adverse Events (AEs)
Secondary Outcome:
  • Cmax
  • Objective Response Rate (ORR)
  • Duration of Response
  • Change from Baseline in the Presence Anti-Drug Antibodies (ADAs)
  • Minimum observed serum concentration (Cmin)
  • Area Under the Concentration-Time Curve
  • Clearance (CL)
  • Volume of Distribution at Steady State (Vdss)

View this trial on ClinicalTrials.gov

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Resources

Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society