Exercise During and After Neoadjuvant Rectal Cancer Treatment

Official Title

A Phase II Randomized Controlled Trial of Aerobic Exercise in Rectal Cancer Patients During and After Neoadjuvant Chemoradiotherapy

Summary:

This study is designed to investigate if aerobic exercise during and after neoadjuvant chemoradiotherapy (NACRT) can improve outcomes for rectal cancer patients. Rectal cancer patients will be randomly assigned to aerobic exercise or usual care. Patients in the aerobic exercise group will be asked to complete 3 supervised high-intensity aerobic interval training (HIT) session/week during NACRT and ≥ 150 minutes/week of unsupervised aerobic exercise after NACRT. Primary hypothesis: aerobic exercise during and after NACRT, compare to usual care, will result in significantly better cardiorespiratory fitness.

Trial Description

Primary Outcome:

  • Change in Cardiorespiratory fitness
Secondary Outcome:
  • Cardiorespiratory fitness
  • Functional fitness
  • Generic quality of life
  • Disease specific quality of life
  • Symptom burden
  • Exercise motivation
  • Eligibility rate
  • Recruitment rate
  • Exercise adherence rate
  • Follow-up assessment rate
  • Safety: Adverse event rate

View this trial on ClinicalTrials.gov

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Resources

Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society