Elotuzumab, Pomalidomide, & Dexamethasone (Elo-Pom-Dex) With Second Autologous Stem Cell Transplantation for Relapsed Multiple Myeloma

Titre officiel

A Phase II Study of Elotuzumab, Pomalidomide, & Dexamethasone (Elo-Pom-Dex) With Second Autologous Stem Cell Transplantation for Relapsed Multiple Myeloma

Sommaire:

Based on the need to improve outcomes post second autologous stem cell transplant (ASCT) for multiple myeloma (MM) and the benefits seen of maintenance treatment following initial ASCT, the natural next step is to evaluate maintenance/continuation therapy following second ASCT. Pomalidomide is active against MM cells refractory to both bortezomib and lenalidomide, making it an ideal choice for continuation therapy following second ASCT. Adding elotuzumab may increase efficacy and also the durability of responses which is essential to improving outcomes following second ASCT.

Description de l'essai

Primary Outcome:

  • Event-free survival (EFS) rate
Secondary Outcome:
  • Overall response rate (ORR)
  • Complete response rate (CRR)
  • Minimal residual disease negative (MRD-negative) rate
  • Event-free survival (EFS)
  • Progression-free survival (PFS)
  • Overall survival (OS)
  • Toxicity of regimen as measured by frequency of adverse events per the number of participants treated

Voir cet essai sur ClinicalTrials.gov

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