The Role of Inflammation in Ocular Tumours
This prospective, non-therapeutic study will determine whether a novel imaging technique can
identify presumptive tumour associated macrophages (TAMs) in patients with ocular tumours.
In this study, we will modify the standard angiography protocol by having patients return
twice in the week following angiography for additional photographs. Photographs will be
obtained 2-7 days after angiography, but without further injection of dye. This technique
contrasts with normal angiography in which photographs are taken during the transit phase of
dye circulation and in the minutes thereafter. Of note, both the dye and the cameras used
for its detection have been approved for clinical use for several decades and are routinely
used in the evaluation of patients with ocular tumours.
We will evaluate 5 groups:
1. Choroidal nevus (low-risk features): requires distinction from melanoma through
2. Choroidal indeterminate melanocytic lesion (high-risk features): requires diagnostic
testing for identification and distinction from nevus and melanoma
3. Choroidal melanoma: requires confirmation of diagnosis and evaluation for potential
4. Suspected metastatic tumour (ie, primary tumour elsewhere): requires identification of
5. Locally treated ocular tumours: requires followup to evaluate response to treatment and
potential change or repeat therapy
View this trial on ClinicalTrials.gov
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