A Phase III Randomized, Controlled Clinical Trial of Pembrolizumab With or Without Platinum-Based Combination Chemotherapy Versus Chemotherapy in Subjects With Advanced or Metastatic Urothelial Carcinoma
The purpose of this study is to determine the efficacy and safety of pembrolizumab (MK-3475)
with or without chemotherapy versus chemotherapy alone in participants with advanced or
metastatic urothelial carcinoma (bladder cancer).
The primary hypotheses are that pembrolizumab plus chemotherapy is superior to chemotherapy
alone with respect to Progression-free Survival (PFS) and Overall Survival (OS) in
participants with programmed cell death ligand 1 (PD-L1) positive tumours and in all
participants (includes those participants with PD-L1 positive tumours and those with PD-L1
View this trial on ClinicalTrials.gov
Print this page and take it to your doctor to discuss your eligibilty and treatment options. Only your doctor can refer you to a clinical trial.
These resources are provided in partnership with the
Canadian Cancer Society