Study of Nivolumab in Combination With Ipilimumab Versus Nivolumab in Combination With Ipilimumab Placebo in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

Official Title

A Double-Blind, Randomized, Two Arm Phase 2 Study of Nivolumab in Combination With Ipilimumab Versus Nivolumab in Combination With Ipilimumab Placebo in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN)

Summary:

A study in patients with metastatic or recurrent squamous cell cancer of the head and neck to evaluate the effectiveness of Nivolumab plus Ipilumumab vs. Nivolumab alone (CheckMate 714)

Trial Description

Primary Outcome:

  • Overall response rate (ORR) in platinum refractory subgroup
  • Duration of Response (DOR) in platinum refractory subgroup
Secondary Outcome:
  • ORR in platinum eligible subgroup
  • Progression Free Survival (PFS) in platinum eligible and refractory subgroups
  • Overall Survival (OS) in platinum eligible and refractory subgroups
  • DOR in platinum eligible subgroup

View this trial on ClinicalTrials.gov

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Resources

Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society