Protein Recommendation to Increase Muscle

Titre officiel

Decreasing the Burden of Sarcopenia in Cancer Through Targeted Nutrition Intervention: A Feasibility Study

Sommaire:

Cette étude de faisabilité porte sur l'efficacité des régimes alimentaires prônant des quantités différentes de protéines et de calories chez les patients atteints de cancer. Notre hypothèse est que les déficits nutritionnels jouent un rôle de taille dans la perte de masse musculaire et que la thérapie nutritionnelle constitue une première étape importante pour renverser ou éviter la perte musculaire et entretenir ou améliorer le fonctionnement physique, la tolérance au traitement et la qualité de vie.

Description de l'essai

Primary Outcome:

  • Change/maintenance in muscle mass
Secondary Outcome:
  • Change in physical function
Severe muscle depletion (sarcopenia) is a common issue among cancer patients and adequate nutrient intake is pivotal to maintain muscle mass. Yet, optimal amounts of protein are undefined for preventing or treating sarcopenia in people with cancer as most methodological approaches to assess protein requirements are expensive, burdensome and unfeasible for this population. This study's overarching goal is to investigate the potential efficacy of diets of different protein content on: 1) muscle mass maintenance (primary endpoint); and 2) improvements on physical function in cancer patients capable of oral nutrition support. Additional study measurements include: energy metabolism (including total body), body composition using multi-compartment models, blood biomarkers, and quality of life. In a randomized controlled trial approach, we will employ high protein feeding (2 g/kg/d, n=16) versus a standard recommendation (1 g/kg/d, n=16) in patients with newly diagnosed colorectal cancer for 12 weeks. Prescribed energy intakes will be framed by the amount of calories to meet energy needs and to support protein synthesis, but prevent fat mass gain. Carbohydrate, fat and protein intake will be adjusted throughout the intervention to achieve the desired rate and amount of energy and protein intake. An oral protein powder supplement made from high-quality whey protein will be provided to the participants to help increase their protein intake as needed. A multivitamin will be given to all participants throughout the study. Participants will receive weekly calls from the study coordinator to ensure adherence to the dietary intervention.

Voir cet essai sur ClinicalTrials.gov

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Ressources

Société canadienne du cancer

Ces ressources sont fournies en partenariat avec Société canadienne du cancer