Study of DPX-Survivac Vaccine Therapy and Epacadostat in Patients With Recurrent Ovarian Cancer

Official Title

A Phase 1b Study of an Immunotherapeutic Vaccine, DPX-Survivac With Low Dose Cyclophosphamide and Epacadostat (INCB024360) in Patients With Recurrent Ovarian Cancer


Immunotherapeutic survivin vaccine DPX-Survivac, low dose oral cyclophosphamide, and IDO1 inhibitor epacadostat will be tested together for the first time in patients with recurrent ovarian, fallopian tube, or peritoneal cancer to determine the safety and potential immune-modulating activity of the combination of these agents.

Trial Description

Primary Outcome:

  • Safety as measured by adverse event reporting (CTCAE)
  • Cell mediated immunity as measured by the antigen specific response in peripheral blood
  • Evaluation of treatment-induced changes in tumour infiltrating lymphocytes
Secondary Outcome:
  • Objective Response Rate
  • Duration of Response
  • Time to Progression
  • Overall Survival

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Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society