A Multiple Dose, Dose Escalation Trial of AEB1102 in Patients With AML or MDS

Official Title

A Phase 1 Dose-Escalation Study of AEB1102 (Co-ArgI-PEG) in Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome Refractory to Hypomethylating Agents

Summary:

This is the first study of the safety of increasing dose levels of AEB1102 in patients with Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome. The study will also evaluate the amounts of AEB1102 in blood, the effects of AEB1102 on blood amino acid levels and the antitumour effects of AEB1102.

Trial Description

Primary Outcome:

  • Maximum Tolerated Dose and Recommended Phase 2 Dose
Secondary Outcome:
  • Safety profile (changes in physical exam, laboratory measures, reported adverse events)

View this trial on ClinicalTrials.gov

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Resources

Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society