Advanced Methods for Cancer Detection by Vaginal Screening

Official Title

Advanced Methods for Cancer Detection by Vaginal Screening (ADVISE): A Pilot Study of Using Vaginal Cell Sampling for Ovarian or Endometrial Cancer Detection


This pilot study is the first step in the development of an new assay that may be further tested as a screening method for ovarian and endometrial cancers.

Trial Description

Primary Outcome:

  • Assay sensitivity and specificity as assessed by the mutation detection rate in tumour and vaginal DNA
  • Patient Acceptance of the methods of DNA collection (Vaginal self-swab and tampon collection)
Most high grade ovarian cancers originate in the fallopian tubes. Since the lining of the fallopian tube opens into the uterine cavity cancer cells from ovarian/fallopian tube cancers can travel through the uterus to the cervix and vagina. Likewise, endometrial cancer cells shed through the cervix into the vagina. It may be possible to develop a screening test for ovarian and endometrial cancers by collecting vaginal cells.

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Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society