MR-Guided High Intensity Focused Ultrasound for Pain Management Of Osteoid Osteoma & Benign Bone Tumours in Children and Adults

Official Title

Magnetic Resonance-Guided High Intensity Focused Ultrasound for Pain Management of Osteoid Osteoma and Benign Bone Tumours in Children and Young Adults

Summary:

The Philips Sonalleve HIFU system is expected to be efficacious in reducing pain scores in patients with painful osteoid osteoma and other benign bone tumours, and in reducing their pain medication usage. No serious adverse effects are expected to result from this treatment.

Trial Description

Primary Outcome:

  • Change in pain intensity scores from baseline related to the site treated target lesion.
Secondary Outcome:
  • Reduction in in pain medication usage (NSAIDS, Opioids).
The objective of this study is to determine if MR-guided high-intensity focused ultrasound (MR-HIFU) is safe and effective technique for alleviating the pain associated with osteoid osteoma and other benign bone tumours in paediatric patients and adults(up to age 40 yrs). This technique meant to be an alternative to the standard-of-care, radiofrequency and laser-based percutaneous ablation. Safety of the technique will be assessed through evaluating non-targeted heating using MRI based temperature mapping. and inspecting patients post treatment for skin burns or other signs of serious adverse events. Efficacy of the technique will be assessed by evaluating/recording patients observed pain, quality of life, and pain medication usage both before and up to 6 months following treatment.

View this trial on ClinicalTrials.gov

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Resources

Canadian Cancer Society

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