Determining the True Incidence of Atrial Fibrillation Before and After Lung Resection

Official Title

Determining the True Incidence of Atrial Fibrillation Before and After Lung Resection

Summary:

Lung resections for pulmonary malignancies offer the best chance of survival for patients, but these procedures carry a significant burden of post-operative morbidity and mortality. Patients are particularly at high risk for post-operative atrial fibrillation (a condition involving irregular heart rhythm). Atrial fibrillation with symptoms can increase the risk of stroke - a blockage in a major blood vessel in the brain, which can potentially result in a disability or even death. The objective of this study is to establish the feasibility of using ambulatory heart rate monitoring to determine the total incidence of atrial fibrillation in the peri-operative period before and after anatomic lung resection for malignancies. The study will also investigate the correlation between atrial fibrillation and rates of stroke and other adverse events, as well as serve to identify the patients that are at a higher risk of developing atrial fibrillation.

Trial Description

Primary Outcome:

  • Monthly rate of patient accrual
  • Patient adherence to monitoring device use-Wear time
  • Patient adherence to monitoring device use-Logging of symptomatic events
  • Number of patients who withdraw from study protocol
Secondary Outcome:
  • Baseline incidence of asymptomatic atrial fibrillation before lung resection
  • The number of post-operative atrial fibrillation events
  • The number of any post-operative recurrent atrial fibrillation events within 14 days of lung resection
  • Total event rate for asymptomatic atrial fibrillation
  • Rate of other non- atrial fibrillation arrhythmia
  • Impact of resection intensity (larger versus smaller resection size) on the development of any atrial fibrillation events
  • Impact of use of minimally invasive surgery on the development of any atrial fibrillation events
  • Measurement of the difference of 90 day mortality in event-free patients and those with atrial fibrillation
  • Measurement of the difference of rates of stroke in event-free patients and those with atrial fibrillation
Novel literature suggests that atrial fibrillation that is asymptomatic may just be as problematic as atrial fibrillation that presents itself with symptoms. The objective of the study is to establish the feasibility of tracking the total incidence of atrial fibrillation in the peri-operative period, including both symptomatic and asymptomatic events, using an ambulatory heart monitor. Additionally, the study aims to estimate the overall incidence of peri- and post-operative atrial fibrillation. These will be accomplished through usage of iRhythm ZIO XT, a small pebble shaped device that will be adhered to the patient's chest for 14 days before and after surgery, to measure how often atrial fibrillation occurs.

View this trial on ClinicalTrials.gov

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Resources

Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society