A Study of Afatinib in Patients With Advanced Cancer With Changes in the HER Gene

Official Title

Molecular Basket Trial In Multiple Malignancies With Common Target Pathway Aberrancies

Summary:

This is a phase 2 study (the second phase in testing a new drug) to see how useful an investigational drug called afatinib is in patients with advanced cancer with changes in the HER gene.

Afatinib is a drug that is approved by Health Canada for the treatment of advanced lung cancer with changes in the HER gene. Afatinib works by attaching to and blocking a protein called HER from working. HER is an important protein that contributes to the growth of cancer cells.

Trial Description

Primary Outcome:

  • Number of patients with complete response
  • Number of patients with partial response
Secondary Outcome:
  • Number of Grade 1 side effects
  • Number of Grade 2 side effects
  • Number of Grade 3 side effects
  • Number of Grade 4 side effects
  • Timeframe of Progression Free Survival

View this trial on ClinicalTrials.gov

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Resources

Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society