Sentinel Lymph Node Mapping of Oral Cancer Using Near-Infrared Fluorescence Imaging
Cervical lymph node involvement, in head and cancer neck patients, is one of the most
important prognostic factors. Currently patients undergo neck dissection removing some or
all nodes and neck involvement is retrospectively determined. Sentinel lymph node (SLN)
identification and biopsy has become clinical practise in other areas including breast,
skin, and gastric cancer. The gold standard for detecting metastatic lymph nodes is
pathological analysis, but the lack of an accurate or clinically accepted way to identify
sentinel lymph nodes in the cervical region has motivated the usage of indocyanine green
(ICG) and near-infrared fluorescence (NIR) imaging (Pinpoint, Novadaq, Waterloo). A
prospective clinical trial using a commercially available NIR system and ICG injection
around the tumour site will evaluate the ability to detect and biopsy sentinel lymph nodes
in head and neck cancer patients.
View this trial on ClinicalTrials.gov
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