GRID Therapy as Palliative Radiation for Patients With Advanced and Symptomatic Tumours

Official Title

Spatially Fractionated Radiation (SFR) Therapy as Palliative Radiation for Patients With Advanced and Symptomatic Tumours

Summary:

Palliative radiation therapy represents 40% of the on-going radiation at the Jewish General Hospital. In a traditional palliative radiation treatment to bulky or radioresistant tumours, radiation therapy schema varies from 24 to 30 Gys given in 3 to 10 fractions, depending on the tumour size, tumour location and tumour pathology. However, for many patients this treatment involves considerable toxicity, travel and time spent at the hospital. Spatially fractionated radiation (SFR) is an alternative technique that consists in delivering one single treatment, given through a grid containing holes. The present study is proposing to validate SFR as a safe and effective mean to palliate patients with symptomatic bulky tumours (more than 8 cm) or with tumours known to be resistant to radiation.

Trial Description

Primary Outcome:

  • Symptom relief, as measured using the CTCAE grading system (v4.0) and pain questionnaire
Secondary Outcome:
  • Acute toxicity of treatment, as measured using the CTCAE grading system (v4.0)
  • Long-term toxicity of treatment, as measured using the CTCAE grading system (v4.0)
  • Cost-effectiveness, as measured by evaluating the cost of the procedure per patient and the efficacy of treatment with regards to symptom relief and tumour response
  • Tumour response, measured on CT-scan

View this trial on ClinicalTrials.gov

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Resources

Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society