A Randomised, Open-label Trial of a Multimodal Intervention (Exercise, Nutrition and Antiinflammatory Medication) Plus Standard Care Versus Standard Care Alone to Prevent/Attenuate Cachexia in Advanced Cancer Patients Undergoing Chemotherapy
Cancer cachexia is a multi-factorial syndrome defined by an ongoing loss of skeletal muscle
mass (with or without loss of fat mass) that cannot be fully reversed by conventional
nutritional support and leads to progressive functional impairment.
There is an urgency for improving management, but there is no consensus on the optimal
treatment for cancer cachexia. Several single therapies for cancer cachexia have been
examined in clinical trials, with disappointing overall results. As multiple factors are
responsible for the development of cachexia, it has been argued that optimal cachexia
interventions should target all components: multimodal therapy for a multimodal problem.
The overall aim of this study is to early prevent the development of cachexia rather than
treatment late in the disease trajectory. From a patient perspective a short term effect
will be to improve physical and psychological function, to reduce symptom burden and to
improve survival. In other words live a longer and better life during and after
chemotherapy. Direct effects of the cachexia intervention are expected to be reduction of
weight and muscle loss, and improved physical activity and quality of life.
View this trial on ClinicalTrials.gov
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