Anti-proliferative Effects of Melatonin and Vitamin D in Breast Cancer
The investigators want to study whether Vitamin D and melatonin can reduce the growth of
cancer cells in women with breast cancer. Studies using cell cultures and animals have shown
that Vitamin D can reduce the spread of cancer. Studies in people have shown that exposure
to sun and eating foods containing high levels of Vitamin D can protect against cancer. As
well, researchers have noticed that an increase in melatonin levels appears to lower the
risk of getting cancer. Melatonin is a hormone secreted by the body during the night while
Women with cancer proven by breast biopsy who are planned for surgery will be included. The
investigators want to see if treatment with Vitamin D (2000 IU daily), or melatonin (20 mg
daily), or both pills together, reduces the growth of cancer cells when compared to
treatment with sugar pills. All women will receive identical appearing pills for
approximately four weeks. The investigators will measure a tumour protein called Ki67 in the
biopsy and in the tumour removed at surgery. Ki67 provides information on how rapidly the
cancer grows. The reduction in Ki67 levels between the biopsy and surgery will be compared
between the four groups.
Vitamin D and melatonin are inexpensive with few side effects. If a reduction in cancer
growth rate is shown then this would provide a strong reason for further large cancer
prevention trials with Vitamin D and melatonin.
View this trial on ClinicalTrials.gov
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