Dual-Energy CT in Patients With Head and Neck Squamous Cell Carcinomas

Official Title

Dual-Energy CT in Patients With Head and Neck Squamous Cell Carcinomas: Assessing Tumour Perfusion and Prediction of Treatment Outcomes


The purpose of this study is to utilize dual-energy computed tomography (DECT) to investigate changes in tumour iodine concentration in patients with head and neck squamous cell carcinomas (HNSCC). Dual-energy computerized tomography could easily replace a standard CT neck with the added benefit of providing functional information that would only be possible with advanced computerized tomography perfusion, magnetic resonance diffusion (MRI) or positron emission tomography (PET) imaging techniques.

Trial Description

Primary Outcome:

  • Correlate iodine quantification with the microvascular density in the biopsy specimen
Secondary Outcome:
  • Utility of dual-energy computerized tomography obtained during chemoradiation therapy to predict treatment response.
Patients with head and/or neck tumours routinely have head and neck imaging completed with a computerized tomography scan, commonly called a CT scan. A CT scan combines a series of x-ray views that are taken from many different angles and uses computer processing to create cross-sectional images inside your body. These cross-sectional images are very thin slices, often less than 1 mm thick and allow the radiologist to examine parts of your tissue very closely. Dual energy computed tomography (DECT) is a fairly new technology that uses both the normal x-ray and also a second less powerful x-ray to make the images. The Ottawa Hospital has scanners in use that are able to take the images that oncologists typically order for patients and can also be set to obtain DECT images at the same time. The purpose of this study is to investigate whether DECT images can provide helpful information to better predict how the tumour will respond to treatment and the likely course of head and neck tumours.

View this trial on ClinicalTrials.gov

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Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society