Whole Brain Radiation Therapy Versus Volumetric Modulated Arc Therapy for Brain Metastases

Official Title

A Randomized Phase II Study of 20 Gy in 5 Fractions Whole Brain Radiation Therapy Versus 15 Gy in 1 Fraction Volumetric Modulated Arc Therapy for One to Ten Brain Metastases

Summary:

Patients with brain metastases with expected life expectancy of 3-6 months are typically treated with radiotherapy to the whole brain giving a dose of 20 Gy over a 5 day period. This study will compare this with volumetric modulated arc therapy (VMAT) which is capable of delivering 15 Gy in one single session to identified disease within the brain but sparing the normal surrounding brain tissue. Primarily the study will assess whether it is possible to recruit sufficient patient numbers to a trial of this type. It will also compare effectiveness, side effects and quality of life between the two treatment methods.

Trial Description

Primary Outcome:

  • Accrual
Secondary Outcome:
  • Intracranial disease control

Other Outcomes:
  • Compare the use of corticosteroids
  • Compare the incidence of retreatment with cranial radiotherapy
  • Compare the incidence of acute and late side effects
  • Compare the time to decline in activities of daily living using the Modified Barthel Index
  • Compare the time to decline in Karnofsky Performance Status < 70
  • Compare the time to decline in cognition
  • Time to decline in quality of life

View this trial on ClinicalTrials.gov

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Resources

Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society