Randomized Phase II Trial of Concurrent Chemoradiotherapy +/- Metformin HCL in Locally Advanced NSCLC
This randomized phase II trial studies how well chemotherapy and radiation therapy given
with or without metformin hydrochloride works in treating patients with stage III non-small
cell lung cancer. Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in
different ways to stop the growth of tumour cells, either by killing the cells, by stopping
them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy
x-rays to kill tumour cells and shrink tumours. Metformin hydrochloride may shrink tumours and
keep them from coming back. It is not yet known whether chemotherapy and radiation therapy
is more effective when given with or without metformin hydrochloride in treating stage III
non-small cell lung cancer.
View this trial on ClinicalTrials.gov
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