Applying Biomarkers to Long-term Effects in Child and Adolescent Cancer Treatment (ABLE Team) - Predictive Biomarkers For Pediatric Chronic Graft-Versus-Host Disease
Chronic graft-versus-host disease (cGVHD) can be hard to diagnose, difficult to manage and
contributes significantly to morbidity and mortality in stem cell transplantation patients.
The research will look into identifying and validating cGVHD biological indicators
(=bio-markers) which will be evaluated whether they can predict a future development of the
The study hypothesis is that a number of previously reported cGVHD bio-markers, known to be
present at the time of cGVHD diagnosis, will also be present at earlier time points, before
Following validation, the bio-markers will be beneficial for finding those patients who are
in higher risk to develop cGVHD.
By identifying the higher-risk group, which is more likely to develop cGVHD, a pre-emptive
therapy might be applied in order to prevent or reduce the prevalence of the disease.
View this trial on ClinicalTrials.gov
Print this page and take it to your doctor to discuss your eligibilty and treatment options. Only your doctor can refer you to a clinical trial.
These resources are provided in partnership with the
Canadian Cancer Society