Prevention of Metabolic Syndrome and Increased Weight Using Metformin Concurrent to Androgen Deprivation Therapy and Radiation Therapy for Locally Advanced Adenocarcinoma of the Prostate
In current clinical practice, an acceptable standard treatment for locally advanced prostate
cancer is radiation therapy in combination with hormone therapy (called Treatment B or Group
B in this study). However, despite our best treatments, there is a risk that the prostate
cancer may eventually return. As well, the hormonal therapy that is given to treat the
prostate cancer is known to cause some harmful effects, with some patients using the
hormones gaining weight, developing diabetes, having increased cholesterol levels, having
increased blood pressure, and/or heart problems.
This study is looking at whether Metformin, a drug that is commonly used to treat diabetes,
can prevent patients from developing some of the harmful effects of the hormonal therapy. In
treating diabetes, Metformin is known to decrease patients' sugar levels and also prevents
patients from gaining weight, decreases their cholesterol levels, decreases the number of
heart problems and allows patients to live longer. As a result, the researchers in this
study are hopeful that Metformin will also be beneficial for men with prostate cancer on
hormonal therapy by preventing them from developing these problems.
View this trial on ClinicalTrials.gov
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