A Phase 1 Study of AZD1775 (MK-1775) Concurrent With Local Radiation Therapy for the Treatment of Newly Diagnosed Children With Diffuse Intrinsic Pontine Gliomas
This phase I trial studies the side effects and the best dose of WEE1 inhibitor AZD1775 when
given together with local radiation therapy in treating patients with newly diagnosed
diffuse intrinsic pontine gliomas. WEE1 inhibitor AZD1775 may stop the growth of tumour cells
by blocking some of the enzymes needed for cell growth. Radiation therapy uses high energy
x-rays, gamma rays, neutrons, protons, or other sources to kill tumour cells and shrink
tumours. Giving WEE1 inhibitor AZD1775 with local radiation therapy may work better than
local radiation therapy alone in treating diffuse intrinsic pontine gliomas.
View this trial on ClinicalTrials.gov
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