Comparison of the Efficacy Between 20% Mannitol and 3% Hypertonic Saline, Given as a Bolus at the Beginning of Elective Supratentorial Craniotomy for Tumour Resection, in Favoring Cerebral Relaxation Evaluated by a Sub-dural Intracranial Pressure Measurement.
Mannitol 20% has long been used to treat elevated intracranial hypertension in trauma and
intensive care settings. More recent data indicate that hypertonic saline may be as
effective or more effective than mannitol for this purpose, with possible fewer side
This study compares both agents in favoring cerebral relaxation during elective
supratentorial procedures for tumour resection.
Study hypothesis: 3% hypertonic saline will provide better cerebral relaxation with fewer
side effects than 20% mannitol.
View this trial on ClinicalTrials.gov
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