Feasibility Study of Genomic Profiling Methods and Timing in Tumour Samples

Official Title

A Feasibility Study of Genomic Profiling Methods and Timing of Sample Collection to Evaluate Clonal Evolution and Tumour Heterogeneity

Summary:

This is a feasibility study to look for genetic alterations in tissue and blood samples that may be useful in determining what treatments may be useful in the patient's cancer care.

Trial Description

Primary Outcome:

  • Patient recruitment for paired core and fine needle biopsy greater than or equal to 50% of those screened or approached.
Secondary Outcome:
  • The rate of acceptable tumour samples from fresh core needle biopsy samples/total number of fresh core needle biopsy samples greater than or equal to 90%
  • The rate of acceptable tumour samples from fresh fine needle biopsy samples/total number of fresh fine needle biopsy samples greater than or equal to 50%
  • Successful analysis of fresh core needle biopsy samples and fresh fine needle biopsy samples greater than or equal to 50%
  • Analysis of fresh core needle biopsy samples and fresh fine needle biopsy samples from time from patient recruitment to final results, less than a defined period of time, in greater than or equal to 90%
  • Actionable genomic result analysis of fresh core needle biopsy samples and fresh fine needle biopsy samples greater than or equal to 30%
As part of the study, patients will have archival tumour tissue collected, and have tumour biopsies and blood samples taken. The samples will be tested for genetic alterations, and the results will be discussed with the patient including potential treatments. If patients agree, after they have received treatment for their cancer and their disease progresses, a second biopsy procedure will be done.

View this trial on ClinicalTrials.gov

Interested in this trial?

Print this page and take it to your doctor to discuss your eligibilty and treatment options. Only your doctor can refer you to a clinical trial.

Resources

Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society