Prospective Liver Tumour (ProLiT) Database

Official Title

Prospective Database of Liver Transplantation for Hepatocellular Carcinoma

Summary:

The investigators propose a prospective, web-based database (developed within the framework of Quickbase, Intuit) which will allow an evaluation of the data for patients with a liver tumour who receive a liver transplant. Each site will continue to transplant according to their own criteria for inclusion on the waiting list. Each centre will be responsible to enter a short list of data points at time of listing, transplant, and at 1 and 2 years post transplant. Data will be gathered prospectively through a web-based anaonymized database, and outcomes analyzed yearly X5 for tumour recurrence and patient survival.

Trial Description

Primary Outcome:

  • Post-transplant survival
A previous retrospective study evaluated the UNOS database of liver transplant recipients for use of total tumour volume (TTV) and alphafetoprotein (AFP) as criteria for selection of candidates for liver transplantation. The results confirmed a prior publication demonstrating that tumours modestly beyond Milan size limitation and irrespective of tumour numbers can achieve excellent outcomes, while providing important insight into which tumours within Milan criteria remain with a high likelihood of recurrence (high AFP). The work has now been published in Hepatology. The investigators propose a prospective evaluation of these composite criteria, using data from patients receiving a liver transplant in order to have a larger population. Centres will continue to transplant according to their own criteria for inclusion on the waiting list. Data will be gathered prospectively through a web-based database (Quickbase, Intuit) and outcomes analyzed yearly for 5 years follow-up for tumour recurrence and patient survival. Each centre will be responsible to enter a short list of data points for their patients at time of listing, time of transplant, and yearly post transplant. Data points have been kept to a minimum in the hope that this will encourage participation in this database. The database will be set up with 3 levels of access: 1. data entry only (one at each site) 2. review site data and composite data from other sites(one at each site) 3. review all sites and aggregate (for analysis and publication) Sites will only be able to edit and review their own patient data. They will be able to view aggregate data from other sites from which all identifiers have been removed. Data will not be used to manage patient care in any way. The data will be used only to evaluate outcomes of patients who had a liver tumour at the time of their liver transplant.

View this trial on ClinicalTrials.gov

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Resources

Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society