Femoral Bone Metastases

Official Title

A Prospective Cohort Study of the Role of Surgery and/or Radiation Therapy for Bone Metastases of the Femur at High Risk of Pathological Fracture

Summary:

Bone is a common site of metastasis for a range of malignancies. Bone metastases have the potential to cause significant morbidity including pain, impairment of ambulation and reduced functional independence. Previous research has shown that pathological fractures are observed in 9 to 29 percent of patients with long bone metastases, and a high proportion of these require surgical intervention to relieve pain and restore function. The goal of this study is to describe the clinical outcomes of patients with femoral metastases at high risk of pathological fracture. Patients referred for treatment of femoral metastases at high risk of fracture will be followed prospectively after undergoing with surgery (± post-operative radiation therapy), or radiation therapy alone. Patient and disease characteristics, ambulatory status and limb function will be documented before treatment. These Clinical outcomes of participants in each treatment group will be measured 6 weeks after treatment, and 3- and 6 months after enrolment, with particular reference to patient-reported outcomes relating to pain, ambulatory status, limb function and quality of life.

Trial Description

Primary Outcome:

  • To describe the ambulatory status at 3 months by intervention (surgery ± radiation therapy, and radiation therapy alone group) - Ambulatory status
Secondary Outcome:
  • To describe patterns of management in patients with femoral metastases at high risk of pathological fracture - Perioperative Morbidity and Mortality for surgical patients; pain score and performance status; QOL
  • To describe patient and disease characteristics of major management groups (surgery ± radiation therapy, radiation therapy alone due to preference, radiation therapy alone due to co-morbid conditions) - Assessment of lower limb function

View this trial on ClinicalTrials.gov

Interested in this trial?

Print this page and take it to your doctor to discuss your eligibilty and treatment options. Only your doctor can refer you to a clinical trial.

Resources

Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society