A Prospective Cohort Study of the Role of Surgery and/or Radiation Therapy for Bone Metastases of the Femur at High Risk of Pathological Fracture
Bone is a common site of metastasis for a range of malignancies. Bone metastases have the
potential to cause significant morbidity including pain, impairment of ambulation and
reduced functional independence. Previous research has shown that pathological fractures are
observed in 9 to 29 percent of patients with long bone metastases, and a high proportion of
these require surgical intervention to relieve pain and restore function.
The goal of this study is to describe the clinical outcomes of patients with femoral
metastases at high risk of pathological fracture. Patients referred for treatment of femoral
metastases at high risk of fracture will be followed prospectively after undergoing with
surgery (± post-operative radiation therapy), or radiation therapy alone. Patient and disease
characteristics, ambulatory status and limb function will be documented before treatment.
These Clinical outcomes of participants in each treatment group will be measured 6 weeks
after treatment, and 3- and 6 months after enrolment, with particular reference to
patient-reported outcomes relating to pain, ambulatory status, limb function and quality of
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