Role of Active Surveillance and Identification of Prognostic Factors for Progression in Early Stage Renal Cell Carcinoma
There is a rising incidence of incidentally detected small renal tumours due to improved
imaging techniques. Traditionally, patients diagnosed with these small renal masses undergo
surgery and therefore there is limited data about the natural history of these tumours.
Several small series have reported that most of these small masses grow slowly and might not
require early intervention and that only some masses grow rapidly requiring immediate
surgery. Presently, the investigators have not been able to identify prospectively which
masses are going to grow slowly. The investigators plan to use computed tomography (CT) and
Magnetic Resonance Imaging (MRI) parameters, microsatellite analysis and tissue analysis to
determine which masses will behave more aggressively. Additionally, the observations on the
natural history of small renal masses need to be validated with a multicentric and
systematically followed cohort.
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