Non-Invasive Prediction of Microvascular Invasion (MVI) in Hepatocellular Carcinoma (HCC) by Assessment of Tumour Oxygenation by Blood Oxygen Level-Dependent Magnetic Resonance Imaging (BOLD MRI)
Liver resection and liver transplantation are the acceptable treatment of Hepatocellular
Carcinoma (HCC). But the long-term survival is unsatisfactory as a result of high rate of
intra and extra hepatic recurrences. Microvascular invasion (MVI) is the most significant
risk factor affecting recurrence-free survival in patients following liver resection and
liver transplantation. Tumour hypoxia (lack of adequate blood supply) is the single most
important factor that predict MVI and post surgical prognosis.
Blood Oxygen Level Dependent (BOLD) MRI is a non-invasive diagnostic method of assessing
tumour hypoxia by detecting signal changes secondary to changes in blood flow and
oxygenation. BOLD MRI assessment of tumour hypoxia in HCC has never been correlated with
pathological confirmation of MVI, the gold standard to assess MVI in HCC. In this study, the
investigators propose to assess the ability of BOLD MRI to provide a discriminating
quantitative threshold of intratumoural oxygenation predictive of MVI.
View this trial on ClinicalTrials.gov
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