A Feasibility Study Evaluating Neoadjuvant Hemithoracic Intensity Modulated Radiation Therapy for Surgically Resectable Malignant Pleural Mesothelioma
Malignant pleural mesotheliomas (MPMs) are tumours associated with asbestos exposure
involving the tissue lining surrounding the lung. Radiation therapy (RT) dramatically
reduces the risk of tumour recurrence within the irradiated area (>90%). But patients
continue to succumb to MPMs due to the tumour spreading outside the chest cavity. This may
be due to tumour cells inadvertently contaminating areas outside the chest cavity during
surgery. The study will look at whether giving a short intense course of chest radiation
just prior to surgery will sterilized these tumour cells and thus, avoid or reduce
contamination of the areas outside the chest cavity. The investigators hypothesize that
short neoadjuvant (pre-operative) hemithoracic RT, followed by immediate planned
extrapleural pneumonectomy (EPP) (+/- adjuvant chemotherapy) will reduce the risk of
intra-operative seeding and reduce the incidence of distant metastatic disease.
View this trial on ClinicalTrials.gov
Print this page and take it to your doctor to discuss your eligibilty and treatment options. Only your doctor can refer you to a clinical trial.
These resources are provided in partnership with the
Canadian Cancer Society